This is an Open Access article: This article has been cited by other articles in PMC. Abstract Background The leaf juice or water decoction of Catharanthus roseus L. Apocyanaceae is used as a folk medicine for the treatment of diabetes all over the world.
Study on the leaf juice of C roseus showed a dose-dependent lowering of blood glucose in both normal and diabetic rabbits comparable to the standard drug, glibenclamide. Study of C roseus, A indica and A sativum showed significant antidiabetic activity for all three medicinal plants supporting its Ayurvedic use for diabetes.
The anti-cancer drugs, vincristine and vinblastine, are derived from the alkaloids of periwinkle. The alkaloid has growth inhibition effects to some human tumors. Vinblastine is used experimentally for treatment of neoplasms and is recommended for Hodgkin's disease and choriocarcinoma.
Vincristine, another alkaloid, is used for leukemia in children. Vinblastin is sold as Velban; vincristine, as Oncovin. Crude extracts from different parts of C roseus was tested for antibacterial activity.
Extracts from the leaves showed significantly higher efficacy. Study suggests that bioactive compounds of CR can be a potentially exploited as antibacterial agents. Study showed pattern of inhibition depends on extraction procedure, part of plant used, state of plant, solvent used, and microorganism tested.
The ethanolic extract was most active against almost all bacterial organisms tested.
Gram positive bacteria were found more sensitive than gram-negative ones. Study isolated two triterpenes and three alkaloids. Two alkaloids, ajmalicine and serpentine showed very potent inhibitory activity against CYP2D6. Study showed increased wound contraction and tensile strength, increased hydroxyproline content and supports the topical use of CR in wound healing.
The effects of triadmefon, a triazole compound on the antioxidant potentials and root alkaloid ajmalicine content were studies in two varieties of C roseus, rosea and alba.
Triadimefon treatment increased the antioxidant potentials and the indole alkaloid ajmalicine more in the rosea variety than the alba variety content. Results suggest triadimefon may be a useful tool for increasing alkaloid production in medicinal plants. C roseus is known to produce a distinct spectrum of terpenoid indole alkaloids.
Study of non-colored phenolics in C roseus characterized three caffeoylquinic acids and 15 flavonol glycosides. The scavenging ability of different plant matrices was assessed and a concentration-dependent protective effect was observed for seeds and tissues, with petals found to be most active.
C roseus leaves extract made significant changes in each cardiovascular parameter after investigation with hypotensive and hypolipidemic effects in leaves extract treated animals.
Study of leaves extract of Cr showed potent anthelmintic activity in experimental adult earthworm Pheretima posthuma.
There was concentration dependent paralysis and decrease in death time. In the study, the control drug Piperazine citrate showed more potent anthelmintic activity compared to the methanol aqueous, ethanol and ethyl acetate extract. Results showed significant anthelmintic activity, more efficient than the standard drug, piperazine citrate.
Study of a dichlormethane: Decreased enzymic activities in liver of diabetic animals were significantly improved after extract treatment.
Increased levels of lipid peroxidation indicative of oxidative stress were also normalized by extract treatment. Study of extracts of leaves showed it can be used as a prophylactic agent in regions with endemic disease but no in pandemic scale. Leaf yielded indole alkaloids and some phenolic compounds.
Vincristine is a dimer-indo-akaloid from the leaves of C. Side effects limits its clinical use. Study summarizes its properties, advances in decreasing side effects, and new phamaceutical approaches.
Study exposed exposed C. Total alkaloid was found decreased in the roots of CdCl2 treated plants. Study evaluated the sub-acute oral toxic effects of methanol leaves extract of C. Fourteen days of oral administration of 0. Study of a plant leaf dichlormethane methanol extract was found to exhibit significant antihyperglycemic effect in alloxan induced diabetic rats.Catharanthus roseus (L.) G.
Don is known as the Madagascan periwinkle or the tropical periwinkle. The botanical nomenclature C. roseus, determined by the Scottish botanist George Don, has been the subject of numerous questions and polemic debates about its .
The Effect of Catharanthus roseus (Kumintang) Leaf Extract on the Arthritis Score and Blood Vessel Density in Fibroblast Growth Factor-2 and Carrageenan-induced Arthritis in .
Catharanthus roseus is an important Ayurvedic medication in traditional medicine. It is potentially used in countries like India, South Africa, China and Malaysia for the healing of diabetes mellitus. Although, the molecular mechanisms behind this effect are yet to be exclusively explored.
Sep 02, · Catharanthus roseus (L.) G. Don (Apocyanaceae) is known with various names (Madagascar periwinkle; Vinca rosea; Lochnera rosea) in India and all over the world. Water decoction of the leaves and/or the whole plant is used as household remedy for diabetes in several countries [ 9 ].
Tsitsirika, Catharanthus roseus, pink periwinkle: Philippine Herbal Medicine - An illustrated compilation of Philippine medicinal plants by DrGodofredo Umali Stuart, with botanical information, chemical properties, folkloric uses and research studies. Periwinkle alkaloids have been used in the treatment of leukemia, Hodgkin's disease, malignant lymphomas, neuroblastoma, Wilms tumor, Kaposi's sarcoma, mycosis fungoides, to improve cerebral blood flow, and treat high blood pressure.